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Clozapine

Clozapine Coupons & Discount Card – Guaranteed Prices from $19.53

generic Clozaril, Versacloz

Clozapine, marketed as Clozaril, is prescribed to treat certain mental health disorders, including schizophrenia and schizoaffective disorders, particularly when other treatments have failed. It also helps reduce the risk of suicide in individuals prone to self-harm. As an atypical antipsychotic, Clozapine works by rebalancing natural brain chemicals, primarily affecting dopamine and serotonin, which influence thoughts, behaviors, and moods. However, Clozapine is not typically the first choice for schizophrenia due to potential side effects such as drowsiness, dizziness, and a significant drop in white blood cell count, which increases the risk of serious infections. Because of these risks, Clozapine is dispensed under a special program called Risk Evaluation and Mitigation Strategies (REMS), requiring regular blood tests to monitor white blood cell levels. Always consult your healthcare provider before starting or adjusting any medication.
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Clozapine WarningsClozapine Side EffectsClozapine InteractionsFAQs

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100MG, Clozapine (30 Tablets)

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$32.58

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Clozapine dosage forms

The average cost for 30 Tablets of Clozapine (generic Clozaril, Versacloz) at 100MG is $24.5 with a free coupon. This is 68% off the average retail price of $61.8
DosageQuantityPrice fromPer unit
100MG30 Tablets$19.53$0.65
25MG30 Tablets$8.32$0.28
50MG30 Tablets$10.87$0.36
200MG30 Tablets$36.28$1.21

Clozapine Warnings

Clozapine is a medication with significant benefits but also carries potential risks. It is primarily prescribed when other treatments are ineffective. Below is a comprehensive safety and warning guide for clozapine, emphasizing the importance of adhering to prescribed protocols and communicating with healthcare providers.

  • White Blood Cell Concerns: Clozapine can lead to a significant decrease in neutrophils, a type of white blood cell, increasing the risk of serious infections. Regular blood tests are mandatory before and during treatment to monitor neutrophil levels. Immediate medical attention is necessary if symptoms like fever, sore throat, or unusual tiredness appear.

  • Heart-related Risks: Clozapine may cause myocarditis, pericarditis, or heart failure. Seek immediate help if you experience chest pain, irregular heartbeat, or shortness of breath. Additionally, it can lead to a slower heartbeat and low blood pressure, particularly when starting or increasing the dose, which may cause dizziness or fainting. Patients are advised to stand up slowly and ensure adequate hydration.

  • Seizure Risk: There is an increased risk of seizures, especially at higher doses or when taken with other seizure-inducing medications. Patients with a history of seizures should inform their healthcare provider. Avoid activities that could be dangerous if a seizure occurs, like driving or swimming.

  • Older Adults with Dementia: There is a heightened risk of fatal side effects in older adults with dementia-related psychosis. Clozapine is not recommended for this population due to these risks.

  • Metabolic Changes: Clozapine may lead to increased blood sugar and cholesterol levels, resulting in weight gain. Regular monitoring and a balanced diet with regular exercise are recommended to manage these effects.

  • Gastrointestinal Effects: Severe constipation and related gastrointestinal issues can occur. Maintaining a diet high in fiber and fluids is crucial. Consult your provider if you experience symptoms like infrequent bowel movements or abdominal pain.

  • Allergic Reactions: Clozapine can cause serious allergic reactions, such as DRESS syndrome, which may affect multiple organs. Fever, rash, or swollen lymph nodes require immediate medical attention.

  • QT Prolongation: This medication can cause a life-threatening heart rhythm disorder known as QT prolongation. Risk factors include other medications that prolong QT, low potassium or magnesium levels, and a history of heart issues.

  • Neuroleptic Malignant Syndrome: This rare but severe condition is characterized by high fever, stiffness, and confusion. Immediate medical care is essential if symptoms occur.

  • Cognitive and Motor Impairment: Clozapine can impair concentration and reaction time, affecting driving or operating machinery. It can also cause involuntary movements, which may become permanent over time. Discuss any such symptoms with your provider.

  • Liver Health: Rare but serious liver issues may arise. Monitoring liver function through regular tests is advised. Watch for symptoms like yellowing skin or dark urine, and report them promptly.

  • Phenylketonuria Consideration: Patients with phenylketonuria should avoid dissolvable clozapine tablets due to phenylalanine content.

It is critical to communicate openly with your healthcare provider about your medical history and any other medications you are taking to minimize risks. In the event of an overdose, seek emergency medical assistance immediately.

Clozapine Side Effects

Common side effects:

  • drooling
  • drowsiness
  • dizziness
  • constipation
  • fast heart rate
  • trouble sleeping
  • nausea
  • headache
  • heartburn

Less common but important to monitor:

  • increased sweating
  • dry mouth
  • weight gain
  • shakiness
  • restlessness
  • rigid movements
  • disturbed sleep
  • diarrhea
  • rash

Serious side effects:

  • seizures
  • uncontrolled muscle movements (tardive dyskinesia)
  • significant heart problems
  • abnormal heartbeat
  • trouble breathing
  • fainting
  • pulmonary embolism symptoms (sudden chest pain or bloody cough)
  • neuroleptic malignant syndrome
  • allergic reactions (rash, swelling, or breathing difficulties)
  • serious liver issues (yellowing skin or eyes, severe abdominal pain, or dark urine)
  • severe infection due to low blood cell count (fever, fatigue, and body aches)

Clozapine Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Clozapine FAQs
What is the drug clozapine used for?

Clozapine is used primarily for the treatment of schizophrenia, particularly in patients who have not responded adequately to other antipsychotic medications. It is also used to reduce the risk of recurrent suicidal behavior in individuals with schizophrenia or schizoaffective disorder.

Clozapine carries a black box warning for several serious risks, including agranulocytosis, which is a potentially life-threatening decrease in white blood cells. It also warns about the risk of seizures, myocarditis, cardiomyopathy, and increased mortality in elderly patients with dementia-related psychosis. Additionally, there is a warning for orthostatic hypotension, bradycardia, and syncope. Regular monitoring and adherence to specific guidelines are essential when prescribing clozapine.

Clozapine was not banned, but its use is highly regulated due to the risk of serious side effects, particularly agranulocytosis, a potentially life-threatening decrease in white blood cells. Because of this risk, patients taking clozapine require regular blood monitoring to ensure their white blood cell counts remain within a safe range. The drug is typically reserved for treatment-resistant schizophrenia or when other antipsychotic medications have failed.

It is generally not recommended to take Xanax (alprazolam) with clozapine without medical supervision. Both medications can cause sedation and respiratory depression, and their combined effects may increase these risks. It is important for individuals to consult their healthcare provider before using these medications together to ensure safety and appropriate monitoring.

The most common cause of death associated with clozapine is agranulocytosis, a condition where there is a dangerously low level of white blood cells, leading to a high risk of severe infections. Regular blood monitoring is required to mitigate this risk.

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