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This medication comes with several important safety considerations that you should be aware of before using it. Review the following points carefully and consult your healthcare provider if you have any questions or concerns.

• Rectal Damage Risk: Improper use of hydrocortisone (Cortenema) can lead to damage to the rectal wall. It is crucial to follow the Patient Instructions meticulously and consult your prescriber or pharmacist if you have any doubts about its usage.

• Increased Infection Risk: Hydrocortisone (Cortenema) can suppress your immune system, increasing the likelihood of infections or worsening existing ones, including viral or fungal infections. Inform your prescriber about any current or past infections. Should you experience symptoms like fever, chills, nausea, vomiting, body aches, fatigue, or pain while using this medication, contact your healthcare provider immediately.

• Vision Concerns: Prolonged use of hydrocortisone (Cortenema) may lead to increased eye pressure, glaucoma exacerbation, and cataracts. If you notice changes in vision such as blurriness or discomfort, consult your prescriber promptly as you may require an eye examination. Those with a history of eye conditions should be particularly cautious.

• Stress Hormone Levels: Corticosteroids like hydrocortisone (Cortenema) can reduce your body's natural stress hormone production, especially at higher doses or with long-term use. Abrupt cessation can cause symptoms such as weakness, nausea, and diarrhea. Typically, these symptoms are temporary and should resolve as your hormone levels normalize. Consult your prescriber for guidance on safely tapering off the medication, likely reducing to one enema every other night for 2 to 3 weeks before stopping completely.

• Mood Alterations: Although rare with rectal corticosteroids, hydrocortisone (Cortenema) can cause mood changes, including depression, personality changes, mood swings, and sleep disturbances. Report any such symptoms to your prescriber.

Contraindications: This medication should not be used if you have the following conditions, as it may result in serious health risks:

• Active fungal infection
• Intestinal procedures

If any of these contraindications apply to you, consult your healthcare provider before using this medication.

When taking this medication, some users may experience common side effects such as pain or burning in the rectum, dizziness, changes in menstrual periods, trouble sleeping, unusual weight gain, increased sweating, acne, or unusual hair growth. These effects are typically mild and often resolve on their own. However, if they persist or worsen, it's important to consult your healthcare provider.

In addition to the common side effects, there are other effects that have been reported, including skin bruising, skin thinning, high blood pressure, and feeling bloated. While these are generally more manageable, you should still seek medical advice if they become bothersome.

More serious side effects, although less common, require immediate medical attention. These include persistent rectal bleeding, unrelenting headaches, swelling of the ankles or feet, increased thirst or urination, vision problems, a puffy face, or thinning skin. Additionally, symptoms such as unusual skin growths, slow wound healing, unusual bruising or bleeding, signs of stomach or intestinal bleeding, severe heartburn, bone pain, easily broken bones, mental or mood changes, muscle weakness or pain, irregular heartbeat, and signs of infection should be promptly addressed by a healthcare professional.

In very rare cases, a serious allergic reaction may occur. Symptoms such as rash, itching or swelling, severe dizziness, and trouble breathing necessitate immediate medical help. This list is not exhaustive, so if you notice any other unusual effects, contact your healthcare provider for advice.