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The following information outlines crucial safety considerations for using this medication. It is important to review these warnings thoroughly and consult with your healthcare provider if you have any questions or concerns.

• Serotonin Syndrome Risk: This medication can potentially lead to serotonin syndrome, a serious condition characterized by excessive serotonin in the brain. This is particularly a concern when taken alongside certain antidepressants, migraine, or pain medications. Symptoms to watch for include rapid heartbeat, sweating, muscle stiffness, fever, and confusion. If you experience any of these, seek medical attention immediately. It is important to inform your pharmacist about all medications and over-the-counter products you are using to avoid interactions.

• Impact on Driving and Concentration: Cyclobenzaprine may induce drowsiness and affect your ability to concentrate, especially if you are over 65 or taking other sedatives. Alcohol can exacerbate these effects, so it should be avoided. Refrain from engaging in activities that require full alertness, such as driving or operating heavy machinery, until you understand how this medication affects you.

• Dry Mouth, Eyes, and Urination Issues: This medication can lead to reduced production of bodily fluids, causing dry mouth and eyes or difficulty urinating. These effects may be more pronounced if you have glaucoma, high eye pressure, or other urinary tract issues, or if you are taking anticholinergic drugs. Notify your healthcare provider about any existing conditions and all medications you are taking. Contact your provider if these side effects become troublesome.

• Caution for Liver Problems: Those with liver issues should exercise caution when using cyclobenzaprine, and it is not recommended for individuals with severe liver conditions. The drug is metabolized by the liver, and impaired liver function can lead to an accumulation of the drug, increasing the risk of side effects like dizziness and drowsiness. Discuss any history of liver problems with your provider to ensure this medication is safe for you.

Contraindications: Cyclobenzaprine should not be used if any of the following conditions apply, as it may pose serious health risks:

• Use of a monoamine oxidase inhibitor (MAOI) within the last 14 days
• Recent heart attack
• Certain heart issues, such as irregular heartbeat, heart block, or heart failure
• Hyperthyroidism

Always consult your healthcare provider if you have any of these conditions before starting this medication.

Common side effects:

• Drowsiness
• Dry mouth
• Dizziness
• Feeling tired
• Headache
• Indigestion
• Nausea
• Constipation

Serious side effects:

• Fast or irregular heartbeat
• Mental changes like confusion or hallucinations
• Diarrhea
• Blurry vision
• Irritability
• Nervousness
• Weakness
• Very serious allergic reaction (rash, severe dizziness, swelling, or trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (such as isocarboxazid, Linezolid, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Drugs that increase serotonin levels (such as SSRIs like Fluoxetine and paroxetine, SNRIs like Duloxetine and Venlafaxine, MDMA, St. John's wort)
• Tricyclic antidepressants (such as Amitriptyline, imipramine)

Interactions with low risk that usually do not require a change in therapy:

• Products causing drowsiness (such as opioid pain relievers like codeine and hydrocodone, alcohol, marijuana, sleep or anxiety medications like Alprazolam, Lorazepam, Zolpidem, other muscle relaxants like Carisoprodol, Methocarbamol, antihistamines like Cetirizine, diphenhydramine)