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Dehydroepiandrosterone (DHEA) is a hormone produced naturally by the adrenal glands, serving as a precursor to male and female sex hormones, including testosterone and estrogen. DHEA levels peak in early adulthood and gradually decline with age. Some individuals take synthetic DHEA supplements, available in various forms such as tablets, capsules, powders, creams, and gels, aiming to counteract this decline. These supplements are often used with the hope of improving physical performance, alleviating symptoms of menopause, and treating depression. However, research on the effectiveness of DHEA supplementation for these purposes has yielded mixed results. While some studies suggest potential benefits, such as slight improvements in depression symptoms and vaginal dryness in postmenopausal women, there is little evidence to support claims of anti-aging effects or enhanced physical performance. Moreover, DHEA use can lead to serious side effects, including an increased risk of hormone-sensitive cancers and adverse effects on cholesterol levels. Therefore, it is advisable to avoid using DHEA supplements without medical supervision.