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Diphenhydramine, commonly known by the brand name Benadryl, is an over-the-counter antihistamine medication used to alleviate symptoms associated with allergies, hay fever, and the common cold. These symptoms can include rash, itching, watery eyes, itchy eyes, nose, throat, cough, runny nose, and sneezing. Additionally, diphenhydramine is effective in preventing and treating nausea, vomiting, and dizziness related to motion sickness. Due to its sedative properties, it is also used occasionally as a sleep aid for individuals aged 12 years and older. The drug functions by blocking histamine, a natural substance in the body that triggers allergic reactions, such as sneezing, itching, and runny nose. Its effectiveness in drying symptoms like watery eyes and a runny nose is due to its ability to inhibit acetylcholine, another natural body substance. It is important to note that diphenhydramine does not cure or shorten the duration of the common cold and can cause serious side effects if not used correctly. It is not recommended for children under 6 years old for treating cold symptoms unless directed by a healthcare professional. Long-acting forms of the medication should not be used in children under 12 years old. Always follow dosage instructions carefully and consult a healthcare provider for safe use. Do not use this medication to induce sleep in children, and avoid using other cough-and-cold medications that may contain similar ingredients. For safe and effective relief of symptoms, consider alternative methods such as maintaining hydration, using humidifiers, or saline nose drops/sprays.