Erlotinib Hcl (bulk) Coupons & Savings Card – Discount Prices from $78738.30

Erlotinib hydrochloride is a white to light yellow powder with a molecular weight of 429.9 g/mol and a melting point between 226°C and 230°C. It is commonly used in research settings to study its effects on various cancer cell lines. For instance, in non-small cell lung cancer (NSCLC) cells, erlotinib has been observed to increase activation of p53 and AMPK, inhibit mTOR activity, and induce autophagy. Additionally, it upregulates p27 expression and downregulates skp2, leading to G1/S phase cell cycle arrest and inhibited cellular growth. In pancreatic ductal adenocarcinoma models, erlotinib inhibits MAPK signaling and increases overall survival rates. In male mouse models of lung adenocarcinoma, it decreases tumor burden. Due to its potential hazards, including being harmful if swallowed and suspected of damaging fertility or the unborn child, it is essential to handle erlotinib hydrochloride with appropriate safety precautions, such as wearing protective gloves and clothing, and storing it under inert gas at temperatures below -10°C.