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Fondaparinux, also known by its brand name Arixtra, is a medication that acts as an anticoagulant, commonly referred to as a blood thinner. It is used to prevent and treat serious blood clots in adults, such as those found in the legs (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). This drug is particularly beneficial following surgeries with a heightened risk of clot formation, including hip fracture, abdominal, knee, or hip replacement surgeries. Fondaparinux works by inhibiting a protein called factor Xa, a key component in the blood clotting process. By blocking this protein, the medication effectively reduces the likelihood of clot formation, thus lowering the risk of potentially fatal complications like heart attacks and strokes. Administered as a once-daily injection under the skin, the dosage of Fondaparinux is typically determined by the specific condition being treated and the patient's body weight. While bleeding is the most common side effect, it is crucial to follow your healthcare provider's advice and discuss any concerns regarding the use of this medication.