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When considering the use of Impavido (miltefosine), it is critical to be aware of several important safety considerations and warnings. Below is a summary of potential risks and precautions to ensure safe usage of the medication:

• Risk to Unborn Babies: Impavido (miltefosine) poses a significant risk to unborn babies, potentially leading to pregnancy loss or birth defects. Women who are pregnant should not use this medication. Additionally, women of childbearing age must confirm a negative pregnancy test before starting the treatment and use effective birth control during the course and for 5 months after the last dose. Consult your healthcare provider for suitable birth control options.

• Fertility Concerns: For males, Impavido can affect sperm properties, such as sperm count and movement, which may temporarily reduce fertility. These changes have been observed to improve within 3 to 6 months after stopping the medication. Animal studies suggest similar potential effects on female fertility. Discuss any concerns with your healthcare provider.

• Impact on Birth Control Pill Absorption: Vomiting or diarrhea during treatment may reduce the effectiveness of birth control pills by affecting their absorption. Use additional non-oral contraceptive methods, like condoms with spermicide, in such cases to prevent pregnancy.

• Kidney and Liver Function: The medication can increase serum creatinine levels, an indicator of kidney function. Regular blood tests are necessary during and for 4 weeks post-treatment to monitor kidney health.

• Bleeding Risks: Treatment for visceral leishmaniasis with Impavido can lead to low platelet counts, increasing the risk of bleeding. Regular monitoring through blood tests is required, and any unusual bleeding or bruising should be reported to your healthcare provider immediately.

• Severe Skin Reactions: Though rare, serious skin reactions may occur. Seek emergency medical attention if you experience symptoms such as peeling rashes, blisters, sores in the mouth, or hives.

• Contraindications: Impavido should not be used by individuals who are currently pregnant or have Sjögren-Larsson Syndrome due to potential health risks.

It is imperative to consult with your healthcare provider to address any concerns or questions related to the use of Impavido (miltefosine) and to ensure it is a safe option for your health needs.

When taking this medication, some individuals may experience common side effects, which are generally mild. These include nausea, motion sickness, headache, stomach pain, diarrhea, fever, dizziness, itching, and vomiting. To minimize stomach upset, it is advised to take the medication with food and stay hydrated, particularly if vomiting or diarrhea occurs, to prevent dehydration and kidney issues.

Other less common side effects might include weakness or tiredness, sleepiness, decreased appetite, constipation, gas, difficulty swallowing, a sensation akin to "pins and needles," testicular pain, skin infections, rash, hives, anemia, swollen or infected lymph nodes, and abnormal liver or kidney test results.

While serious side effects are rare, they warrant immediate medical attention. These include easy bruising or bleeding, bloody or black stools, signs of kidney problems like changes in urination, yellowing of the eyes or skin, dark urine, and severe testicular pain or swelling. Particularly concerning are potential eye problems, which can lead to permanent blindness; symptoms such as sensitivity to light, eye pain or redness, increased tearing, blurry vision, and loss of vision should be promptly reported to a healthcare provider. Additionally, a severe allergic reaction is possible and requires urgent medical care if symptoms such as rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing occur.

This summary does not cover all possible side effects. If you experience any unusual effects, consult your healthcare provider for further advice.