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The use of Isentress (raltegravir) comes with important safety considerations. It is essential to understand and be aware of the potential risks and necessary precautions related to its use. Please consult your healthcare provider if you have any questions or concerns.

• Severe Skin and Allergic Reactions: There is a risk of severe and potentially life-threatening skin reactions, such as Stevens-Johnson syndrome, as well as serious allergic reactions. If you experience a severe rash, rash with fever, blisters, peeling skin, mouth sores, swelling of the face, or difficulty breathing, discontinue use immediately and seek emergency medical attention.

• Immune System Overactivity: Starting Isentress (raltegravir) for HIV treatment may trigger an intense immune response known as immune reconstitution syndrome. As your immune system strengthens, it may start fighting previously untreated infections, leading to significant inflammation. This is particularly a risk if you have an untreated infection.

• Risk of Muscle Damage: Some adults using Isentress or its HD film-coated tablets have reported elevated creatine kinase levels, indicating muscle damage, which can lead to conditions such as rhabdomyolysis. This severe muscle breakdown can be serious and potentially cause kidney damage. Seek immediate medical attention if you experience symptoms like severe muscle pain, widespread weakness, or brownish-red urine. This risk increases if you are taking other medications known to cause muscle issues or have a history of rhabdomyolysis.

• Phenylketonuria (PKU) Consideration: The chewable tablets of Isentress (raltegravir) contain phenylalanine from the artificial sweetener aspartame, which is harmful to individuals with phenylketonuria (PKU). If you have PKU, consult your healthcare provider for alternative formulations of Isentress that are safer for your condition.

Be sure to follow your healthcare provider's guidance and report any adverse effects or concerns promptly. There are no specific contraindications listed for Isentress (raltegravir).

When taking this medication, you might experience some common side effects such as headaches, nausea, and trouble sleeping. These are generally mild, but if they persist or worsen, it’s advisable to consult your healthcare provider. Other less common side effects include dizziness, fatigue, and elevated liver enzymes. Monitoring these symptoms can be helpful, and contacting a healthcare provider is recommended if they become concerning.

In rare cases, more serious side effects can occur that require immediate medical attention. Severe muscle damage is a possibility, which may manifest as intense muscle pain, weakness, or brownish-red urine. Additionally, a severe skin or allergic reaction could occur, presenting with symptoms like rash, blisters, mouth sores, or swelling of the face and lips, as well as difficulty breathing.

Furthermore, as your immune system strengthens, it might react to infections previously present, potentially causing symptoms to resurface. Keep an eye out for severe fatigue, unexplained weight loss, persistent muscle aches, or numbness. Changes in body fat distribution are also possible with this drug, with increased fat in the upper back and stomach, and decreased fat in the arms and legs.

Lastly, signs of kidney problems, such as changes in urine output, or liver issues, indicated by dark urine and yellowing of the eyes or skin, should be taken seriously. Always reach out to a healthcare professional if you experience these or any other unusual symptoms.