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Anakinra, marketed as Kineret, is an injectable medication primarily utilized for managing rheumatoid arthritis (RA), especially in cases where other treatments have been ineffective. It is distinctively recognized as the only FDA-approved RA medication that inhibits a specific protein known as interleukin-1 (IL-1), which is responsible for causing inflammation, swelling, and pain in the joints. Beyond RA, Anakinra is also prescribed for certain genetic disorders like cryopyrin-associated periodic syndromes (CAPS), including neonatal-onset multisystem inflammatory disease (NOMID), and for the treatment of Deficiency of Interleukin-1 Receptor Antagonist (DIRA). In these conditions, Anakinra helps alleviate symptoms such as fever, rash, joint pain, vomiting, and headaches by blocking the effects of IL-1, thus reducing inflammation. Anakinra is administered through an injection under the skin, typically on a daily basis. In November 2022, it received Emergency Use Authorization (EUA) from the FDA for improving survival rates and reducing hospital stays in certain hospitalized patients with COVID-19, particularly those suffering from pneumonia and requiring supplemental oxygen. As a biologic disease-modifying anti-rheumatic drug (DMARD), Anakinra’s role is to mitigate the inflammatory response by hindering IL-1 activity. For comprehensive guidance and personalized advice, it is essential to consult with healthcare professionals such as doctors, nurses, or pharmacists prior to using Anakinra or any other medication.