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Naloxone is a crucial medication used for the emergency treatment of opioid overdose in both adults and children. It acts by rapidly reversing the effects of opioids, helping to restore normal breathing within 2 to 3 minutes. However, its effects are temporary, lasting only 30 to 90 minutes, so it's essential to seek medical assistance immediately after administering it. Naloxone is available in two forms: a nasal spray (such as Kloxxado, Narcan, and generics) and an auto-injector (Zimhi), and can be obtained without a prescription. This medication belongs to a group of drugs known as opioid antagonists, which work by blocking the action of opioids on the brain. By doing so, it prevents the opioids from affecting the receptors that control breathing and other vital functions. In addition to treating opioid overdoses, naloxone can be used via intravenous injection to raise blood pressure in septic shock and to counteract slowed breathing post-surgery caused by opioids. If someone shows signs of a serious overdose, such as extreme drowsiness, breathing difficulty, very small pupils, slow heartbeat, or low blood pressure, administer naloxone immediately, even if unsure of the cause. Delayed treatment can lead to permanent brain damage or death. Always seek professional medical advice and follow up with healthcare providers after naloxone administration to ensure comprehensive care.