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The following safety and warning information is crucial for the safe use of Trileptal (oxcarbazepine). Please read carefully and reach out to your healthcare provider if you have any questions or concerns.

• Low Blood Sodium Levels: Trileptal may cause low sodium levels in the blood, particularly within the first three months of treatment. While many individuals do not show symptoms, regular blood tests are recommended to monitor sodium levels. Seek immediate medical attention if you experience weakness, confusion, headache, or memory issues, as these may be signs of a medical emergency. This risk is heightened for older adults and those on medications that lower sodium levels.

• Severe Allergic and Skin Reactions: Life-threatening allergic reactions, including facial swelling and anaphylaxis, are possible. Inform your healthcare provider if you have a known allergy to carbamazepine (Tegretol). Individuals of Asian descent and those with specific genetic markers are at increased risk.

• Risk of Suicidal Thoughts: Trileptal may increase the risk of suicidal thoughts or behaviors, potentially occurring within the first week of treatment. If you or someone around you notices signs such as anxiety, panic attacks, irritability, or restlessness, seek medical help immediately. The risk is greater for those with a history of depression or mental health disorders.

• Cognitive and Motor Impairment: Trileptal can cause difficulty with speech, concentration, and movement, in addition to extreme dizziness and sleepiness. These effects may be intensified if combined with other substances that induce drowsiness or dizziness, such as benzodiazepines, muscle relaxants, or alcohol. Avoid driving or engaging in activities that require alertness until you understand how Trileptal affects you. Consult your healthcare provider if these symptoms are severe.

• Higher Risk for Other Seizures: Although effective in controlling seizures, Trileptal can potentially worsen them, especially in children. If you notice increased seizure activity, discontinue use and seek immediate medical attention.

• Withdrawal: Abruptly stopping Trileptal can increase seizure risk. Do not discontinue use without consulting your healthcare provider, who can guide you on how to taper the medication safely.

• Contraindications: Do not use Trileptal if you have a past allergy to Aptiom (eslicarbazepine). Always discuss your medical history with your healthcare provider before starting any new medication.

Common side effects:

• dizziness
• drowsiness
• tiredness
• nausea
• vomiting
• headache
• diarrhea
• runny nose

• sore throat

  Less common but important to monitor:

• constipation
• heartburn
• poor balance

• nervousness

  Serious side effects:

• severe allergic reactions
• severe dizziness
• trouble breathing
• very serious skin reactions
• skin rash
• blisters
• peeling
• itching
• low blood sodium levels
• severe nausea
• extreme drowsiness
• confusion
• seizures
• depression
• suicidal thoughts
• mood changes

Interactions with high risk of serious adverse effects and should be avoided:

• Cabotegravir
• Doravirine
• Rilpivirine
• Eslicarbazepine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Orlistat
• Alfentanil
• Amiodarone
• Benzhydrocodone
• Buprenorphine
• Calcifediol
• Carbamazepine
• Cilostazol
• Citalopram
• Clarithromycin
• Cobicistat
• Codeine
• Daclatasvir
• Darunavir
• Desogestrel
• Dienogest
• Dihydrocodeine
• Dolutegravir
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Dronedarone
• Drospirenone
• Elvitegravir
• Enzalutamide
• Estradiol
• Ethinyl Estradiol
• Ethynodiol
• Etonogestrel
• Fentanyl
• Fosphenytoin
• Gestodene
• Hemin
• Hydrocodone
• Ifosfamide
• Lacosamide
• Ledipasvir
• Levonorgestrel
• Linagliptin
• Lumacaftor
• Lumateperone
• Medroxyprogesterone
• Meperidine
• Mestranol
• Methadone
• Mitotane
• Naloxegol
• Nifedipine
• Nomegestrol
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Oxycodone
• Paclitaxel
• Palbociclib
• Panobinostat
• Pentazocine
• Perampanel
• Phenobarbital
• Phenytoin
• Rifampin
• Rivaroxaban
• Segesterone
• Sertraline
• Simeprevir
• St John's Wort
• Sufentanil
• Tacrolimus
• Tenofovir Alafenamide
• Tolvaptan
• Tramadol
• Tranylcypromine
• Ubrogepant
• Velpatasvir
• Vilazodone
• Voxilaprevir

Interactions with low risk that usually do not require a change in therapy:

• Felodipine
• Ginkgo
• Lamotrigine
• Ospemifene
• Simvastatin
• Valproic Acid
• Verapamil