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Penciclovir is a prescription antiviral cream used to treat cold sores, also known as herpes labialis, in individuals aged 12 and older who experience recurrent outbreaks. This medication, available under the brand name Denavir and as a generic, should be applied to the lips and around the mouth every two hours while awake, typically for a duration of four days. It is most effective when used at the onset of cold sore symptoms. Penciclovir works by inhibiting the replication of the herpes simplex virus, thereby speeding up the healing process and alleviating symptoms such as tingling, pain, burning, and itching. While it does not cure herpes or prevent future occurrences, it can significantly reduce symptom severity. Some users may experience mild skin irritation, but side effects are generally uncommon. Always consult with a healthcare provider before starting any new medication.