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Please pay careful attention to the following safety information regarding potential risks associated with the use of this medication. Consult your healthcare provider if you have any concerns or questions.

• Brain-related Side Effects: Famotidine (Pepcid AC) may lead to neurological side effects, including confusion, delirium, hallucinations, agitation, seizures, and weakness. Individuals with kidney problems are at a higher risk as their kidneys may not efficiently metabolize the drug, leading to increased blood levels and side effects. If you have kidney issues, your healthcare provider may need to adjust your dosage. Discuss with your provider if you have any kidney conditions before using this medication.

• Potential Cancer Risk: In rare cases, persistent heartburn may indicate a more serious condition, such as stomach cancer. Famotidine (Pepcid AC) might alleviate heartburn symptoms, potentially masking these warning signs. If your heartburn persists after completing the treatment, contact your healthcare provider for further evaluation and possible testing for conditions like stomach cancer.

• Contraindications: Do not use this medication if you have a severe allergy to other histamine-2 (H2) antagonists, as it may pose serious health risks. Consult your healthcare provider if this applies to you before starting treatment with Famotidine (Pepcid AC).

Ensure to follow the guidance of your healthcare provider and report any unusual symptoms or concerns during treatment.

When taking this medication, you might experience some common side effects, such as headache, dizziness, constipation, or diarrhea. These are generally mild and should not cause alarm, but do reach out to your healthcare provider if they persist or worsen. Other side effects that have been noted include fever, fatigue, vomiting, nausea, upset stomach, dry mouth, and dry skin. While these are not frequent, it's important to monitor how you feel and consult your healthcare provider if any of these become severe.

There are some serious side effects that require prompt medical attention. These include symptoms like easy bruising or bleeding, persistent sore throat, fever, chills, mental or mood changes such as restlessness or confusion, and hallucinations. If you experience any of these, it is crucial to contact a healthcare provider immediately. In rare cases, a very serious allergic reaction may occur, characterized by a rash, itching or swelling (especially on the face, tongue, or throat), severe dizziness, or trouble breathing. Seek medical help right away if these symptoms arise.

It is important to be vigilant while using this medication and report any unusual side effects to your healthcare provider. This summary does not include all possible side effects, so if you notice anything concerning, do not hesitate to seek professional advice.

Famotidine, known by its brand name Pepcid AC, can interact with various medications and supplements. It's important to inform your doctor and pharmacist about all the medications, vitamins, and supplements you're taking, whether they are prescription or over-the-counter. This is not a complete list, so always consult healthcare professionals for guidance.

Certain medications should not be used with famotidine. These include bepridil, cisapride, dofetilide, dronedarone, mesoridazine, pimozide, piperaquine, saquinavir, sparfloxacin, terfenadine, thioridazine, and ziprasidone. If you're taking any of these, your doctor may adjust your treatment plan.

Other medications may require caution or dose adjustment when taken with famotidine. These include acalabrutinib, atazanavir, dasatinib, certain azole antifungals like itraconazole and ketoconazole, and pazopanib, among others. Famotidine reduces stomach acid, which can affect how well your body absorbs these drugs.

Additionally, avoid using famotidine with other H2 blockers such as cimetidine, nizatidine, or ranitidine, as this could lead to excessive acid reduction. Always follow your healthcare provider's instructions to ensure safe and effective use of your medications.