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The following information outlines important safety precautions and potential risks associated with the use of Pliaglis (lidocaine/tetracaine). It is crucial to review these warnings and consult your healthcare provider with any concerns.

• Methemoglobinemia Risk: Pliaglis can induce methemoglobinemia, a condition impairing blood's oxygen delivery. Symptoms include bluish skin, breathing difficulties, fatigue, seizures, coma, or death. Seek immediate medical attention if you experience these symptoms, particularly if you have G6PD deficiency or heart/lung issues.

• Overabsorption Risks: Excessive absorption of Pliaglis can cause severe side effects. Adhere strictly to the prescribed dose and application area. Avoid prolonged application, covering with a tight bandage, or simultaneous use with other local anesthetics, as these can exacerbate absorption.

• Children and Pets Safety: Ensure Pliaglis is stored securely out of reach of children and pets. Always use the child-resistant cap and dispose of dried cream film safely to prevent accidental exposure.

• Allergic Reactions: Severe allergic reactions, including hives, facial swelling, or breathing difficulties, may occur. Obtain medical assistance immediately if these symptoms develop.

• Eye Irritation: Contact with eyes can result in severe irritation and loss of sensation. Wash hands post-application and rinse eyes with water or saline if exposed. Protect the eye until sensation returns and consult a provider if irritation persists.

Contraindications: Avoid using Pliaglis if you have sensitivities to lidocaine, tetracaine, other local anesthetics, or para-aminobenzoic acid (PABA). Consult your healthcare provider in such cases to discuss alternative treatments.

When using this medication, some common side effects may include temporary redness, stinging, changes in skin color, or swelling at the application site. These effects are usually mild and should not cause alarm, but if they persist or worsen, it is advisable to consult your healthcare provider. Other mild side effects that might occur include rash, itching, dry skin, headache, dizziness, or fever. These are generally manageable, but monitoring their progression is important.

On a more serious note, although rare, there are potential severe side effects that require immediate medical attention. These include symptoms associated with blood problems such as methemoglobinemia, which may present as bluish skin, unusual tiredness, shortness of breath, seizures, or even coma. Additionally, a severe allergic reaction may occur, characterized by a rash, hives, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. These symptoms necessitate urgent medical care.

In summary, while most users experience mild side effects, being vigilant about any severe reactions is crucial for your safety. If any severe symptoms arise, prompt medical intervention is essential.