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It is crucial to be aware of the potential risks and necessary precautions when using lansoprazole (Prevacid). Below is essential safety information to guide you in using this medication responsibly.

• Symptom Concealment Risk: Frequent heartburn may signal a more severe condition like stomach cancer. If heartburn worsens or persists, or if you experience poor appetite, unexplained weight loss, or weakness, contact your healthcare provider promptly.

• Kidney Concerns: Lansoprazole (Prevacid) may lead to sudden kidney problems. Be vigilant for symptoms such as changes in urination, nausea, weakness, fever, rash, or joint pain, and consult your provider if these occur.

• Severe Diarrhea Risk: This medication may increase the risk of Clostridioides difficile infection, particularly in individuals over 65, those recently hospitalized or in nursing homes, or with weakened immune systems. Report severe or watery diarrhea, fever, abdominal pain, or nausea to your provider immediately.

• Bone Fracture Risk: Prolonged use or high doses of lansoprazole (Prevacid) can increase the risk of fractures in the hip, wrist, or spine. Patients with previous fractures or osteoporosis should discuss their risk with their provider before use.

• Skin Reactions: Serious skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis, have been reported. Seek immediate medical attention if you experience fever, body aches, rash, peeling skin, blisters, or facial swelling.

• Lupus Development: Some users may develop lupus or experience worsening symptoms. Symptoms, including joint pain and rash, usually improve within 1 to 3 months after discontinuation. Contact your provider if symptoms arise.

• Vitamin and Mineral Deficiencies: Long-term use can lead to low vitamin B12 and magnesium levels. If you have been using this medication for over three years or experience symptoms like dizziness, muscle weakness, pale skin, tiredness, or tingling, consult your provider.

• Drug Interactions: Certain drugs can alter the effectiveness and side effects of lansoprazole (Prevacid). Avoid St. John’s Wort and rifampin, which can decrease its effectiveness.

• Phenylketonuria (PKU) Caution: The orally disintegrating tablets contain phenylalanine, posing a risk for individuals with PKU. Consider using the capsule form and consult your provider if uncertain.

Contraindications:

• Do not use if you have a history of allergy to PPIs or are taking Edurant (rilpivirine) or rilpivirine-containing medications like Complera. Always consult your healthcare provider if you have concerns about these contraindications.

When using this medication, there are some side effects that you may experience. Common side effects include diarrhea and abdominal pain, which are generally mild. If these symptoms persist or worsen, it's advisable to consult with your healthcare provider for guidance. Additionally, some individuals may report nausea or constipation. These effects are typically manageable, but seeking medical advice is recommended if they become bothersome.

There are also some serious side effects that, while rare, require immediate attention. These include severe stomach pain or persistent diarrhea, which could indicate a severe intestinal condition linked to C. difficile bacteria. If you notice blood or mucus in your stool, or if diarrhea does not cease, it is crucial to seek medical help right away. Avoid using anti-diarrhea or opioid products as they might worsen the condition.

In rare cases, symptoms of kidney problems may occur, such as changes in urination patterns, fever, or painful urination. Additionally, signs of lupus, like worsening joint pain or a rash on the arms or cheeks, need prompt medical evaluation. Long-term use of proton pump inhibitors, like lansoprazole, might lead to vitamin B-12 deficiency, signaled by unusual weakness, a sore tongue, or tingling in the hands or feet.

A serious allergic reaction to this drug is uncommon, but if you experience symptoms such as fever, swollen lymph nodes, rash, or trouble breathing, immediate medical attention is required. Always stay vigilant for any side effects, and contact your healthcare provider if you notice anything unusual.

Lansoprazole, a medication used to reduce stomach acid, can interact with several other drugs. It is essential to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal supplements.

One significant interaction is with methotrexate, especially in high doses. Lansoprazole can also alter the absorption of certain medications that need stomach acid to work effectively, such as ampicillin, atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, and specific azole antifungals like itraconazole, ketoconazole, and posaconazole.

Rilpivirine should not be used with lansoprazole. For medications like acalabrutinib, amphetamine, atazanavir, benzphetamine, bosutinib, capecitabine, cilostazol, citalopram, clopidogrel, dacomitinib, dasatinib, delavirdine, dextroamphetamine, erlotinib, eslicarbazepine acetate, gefitinib, ketoconazole, ledipasvir, lisdexamfetamine, methamphetamine, mycophenolate mofetil, nelfinavir, neratinib, nilotinib, octreotide, pazopanib, pexidartinib, saquinavir, secretin human, selpercatinib, sunitinib, velpatasvir, vismodegib, and voriconazole, use is typically not recommended unless absolutely necessary. If these are prescribed together, your doctor might adjust the dosage or frequency.

Additionally, when taken with drugs like acenocoumarol, dicumarol, levothyroxine, phenprocoumon, tacrolimus, and warfarin, there could be an increased risk of side effects, but such combinations might still be the best treatment in some cases. Again, your healthcare provider may alter the dosage or usage.

Lastly, lansoprazole is quite similar to dexlansoprazole, so avoid using them simultaneously. This medication can also impact certain lab tests, potentially leading to incorrect results, so ensure that the lab staff and all your doctors are aware if you are taking lansoprazole.