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Promethazine is a medication used to address various conditions such as allergies and motion sickness, and to manage nausea and vomiting associated with surgical procedures. It is also beneficial for alleviating symptoms like rash, itching, and a runny nose caused by allergies. Furthermore, it assists in inducing relaxation and mild sedation before and after surgeries, and enhances the efficacy of certain opioid pain relievers. Available as a rectal suppository, Promethazine is a suitable option for those who cannot take oral medications. It functions by blocking histamine, dopamine, and acetylcholine, which are chemicals involved in allergic reactions and other bodily responses. This action helps reduce symptoms of allergies and prevent nausea and vomiting. Commonly experienced side effects of Promethazine include drowsiness and dizziness. Promethazine is available in both brand-name and generic forms, and it should be used under the guidance of healthcare professionals to ensure safety and effectiveness.