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This medication carries significant risks and requires careful attention to usage guidelines to ensure safety. Below are key warnings and precautions to consider:

• Risk of Abuse and Addiction: This drug has a high potential for misuse and addiction, which can result in overdose and death. It is crucial to take the smallest effective dose for the shortest duration necessary. Consult your healthcare provider if symptoms persist after five days of use.

• Breathing Issues: Severe breathing problems, including potentially fatal respiratory depression, can occur, particularly in individuals over 65, those with asthma or COPD, or those with genetic factors that enhance codeine breakdown. Combining this medication with alcohol or other sedatives can exacerbate these issues. Seek emergency medical help if you experience symptoms like slow breathing, sleepiness, or confusion.

• Overdose Risks: Accurate dosing is essential to prevent overdose. Use only the provided measuring device for liquid forms, and store the medication securely away from children. Symptoms of an overdose include slow breathing, muscle weakness, and unresponsiveness. In case of overdose, seek emergency assistance immediately. Naloxone (Narcan) may reverse opioid overdose effects; discuss its use with your healthcare provider.

• Interactions with Other Substances: This medication can interact with other drugs, altering its effectiveness or increasing side effects. Medications like erythromycin, ketoconazole, and ritonavir can raise drug levels, while others like phenytoin and rifampin can lower them. Always consult your healthcare provider before starting or stopping any medication.

• Effects on Pregnant Individuals: Pregnant women should discuss risks and benefits with their doctor. Long-term use during pregnancy can result in neonatal opioid withdrawal syndrome, which can be life-threatening. This condition presents with symptoms like persistent crying and feeding difficulties in newborns. Use the lowest effective dose for the shortest time to mitigate risks.

• Low Blood Pressure: This drug may cause a drop in blood pressure, leading to dizziness or fainting, especially when standing up. Those taking blood pressure medications or certain antipsychotics should be particularly cautious.

• Hormonal Effects: Prolonged use may lead to adrenal insufficiency, characterized by symptoms such as nausea, fatigue, and low blood pressure. Your healthcare provider should evaluate these symptoms to provide appropriate treatment.

• Seizure Risk: If you have a history of seizures, this medication may increase their frequency or severity. Inform your healthcare provider if your condition worsens.

Contraindications: Do not use this medication if you are under 12 years old, have severe respiratory issues, or have had recent surgery like tonsil or adenoid removal. Additionally, it should not be used if you have a stomach blockage or are currently taking or have recently taken an MAOI.

For any concerns or unusual symptoms, contact your healthcare provider promptly to ensure safe and effective use of this medication.

This medication can result in some common side effects, which are generally mild and may include drowsiness, dizziness, headache, blurred or double vision, upset stomach, nausea, constipation, dry mouth, and shortness of breath. If these persist or worsen, it is advisable to contact a healthcare provider. To alleviate dry mouth, consider using sugarless candy or gum and staying hydrated. Getting up slowly from sitting or lying positions can help reduce dizziness.

Serious side effects are rare but require immediate medical attention. These include severe breathing difficulties, mental or mood changes such as confusion or hallucinations, irregular heartbeat, and symptoms of allergic reactions like rash or swelling, especially of the face, tongue, or throat. Additionally, some individuals may experience serious mental and mood changes or breathing problems due to the conversion of codeine or dihydrocodeine into stronger opioids.

In very rare cases, serious allergic reactions can occur. If you notice symptoms such as severe dizziness, trouble breathing, or swelling, seek urgent medical help. While most people using this medication do not experience severe side effects, it is crucial to be vigilant and seek medical advice if any unusual symptoms occur.

When using codeine/chlorpheniramine, be aware that it may interact with various medications and substances. These include certain skin-applied antihistamines (like diphenhydramine cream), naltrexone, and samidorphan. Combining this medication with other products that cause drowsiness or breathing difficulties, such as other opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana, sleep aids (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or additional antihistamines (e.g., cetirizine, diphenhydramine), may heighten the risk of significant side effects, including severe drowsiness and breathing issues.

It is crucial to inform your doctor or pharmacist about all medications and supplements you are taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products. Check the labels of all your medicines, as some may contain ingredients that can lead to drowsiness, and consult your pharmacist regarding safe usage.

Additionally, certain drugs can influence how this medication is metabolized and eliminated from your body, potentially altering its effectiveness. This includes azole antifungals (like ketoconazole), bupropion, fluoxetine, macrolide antibiotics (like erythromycin), paroxetine, quinidine, rifamycins (like rifabutin, rifampin), ritonavir, and some seizure medications (like carbamazepine, phenytoin).

Lastly, this medication could interfere with specific laboratory tests, such as those measuring amylase/lipase levels or allergy skin tests, which may result in incorrect outcomes. Ensure that all healthcare providers and laboratory staff are aware that you are using this medication.