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This safety information highlights the critical risks and warnings associated with the use of solifenacin (Vesicare). Please review this carefully and consult your healthcare provider if you have any concerns.

• Angioedema (Swelling and Breathing Problems): Use of solifenacin (Vesicare) has been linked to angioedema, a rare but serious condition causing swelling in areas such as the face, throat, tongue, or eyes. Swelling in the tongue or throat can be life-threatening as it may obstruct breathing. Seek immediate medical attention if you experience difficulty breathing or sudden swelling of the face or throat.

• Nervous System Side Effects: Solifenacin (Vesicare) may cause drowsiness, dizziness, headaches, confusion, and hallucinations. Be vigilant for these symptoms, especially when initiating treatment or after a dose increase. Inform your healthcare provider if these effects interfere with daily activities. Avoid driving or engaging in tasks that require full attention until you know how the medication affects you. Interaction risk: Other medications causing nervous system effects.

• Digestive System Precautions: This medication is generally not advised for individuals with conditions leading to reduced gut movement. Those with intestinal blockages should not take solifenacin (Vesicare) as it may exacerbate their condition.

• Glaucoma Considerations: If you have glaucoma, inform your healthcare provider before starting solifenacin (Vesicare) to discuss potential risks. This medication can worsen certain types of glaucoma.

• QT Prolongation (Heart Rhythm Issue): High doses of solifenacin (Vesicare) have been associated with QT prolongation, a heart rhythm disorder. Symptoms such as chest pounding, chest pain, shortness of breath, or faintness require immediate medical attention, as they may indicate an irregular heart rhythm. Interaction risk: History of QT prolongation, other medications causing similar heart rhythm issues, high doses of solifenacin (Vesicare).

Contraindications:

Avoid using solifenacin (Vesicare) if you have any of the following conditions, as it may result in serious health risks:

• Uncontrolled narrow-angle glaucoma.
• Urinary retention, such as the inability to urinate or fully empty the bladder, often due to prostate issues.
• Blockages in the stomach or intestines.

Consult your healthcare provider if you have these conditions before taking solifenacin (Vesicare).

When taking this medication, you might encounter some common side effects that are generally mild and manageable. These include dry mouth, constipation, drowsiness, stomach upset, blurred vision, dry eyes, headaches, and feelings of unusual tiredness or weakness. To help with dry mouth, consider using sugarless candy or gum, drinking water, or trying a saliva substitute. For constipation, incorporating dietary fiber, staying hydrated, and regular exercise can be beneficial.

In some cases, users have reported other side effects such as dizziness, nausea, indigestion, and urinary tract infections. These are typically not serious but should be discussed with a healthcare provider if they persist or become bothersome.

However, there are rare but serious side effects that require immediate medical attention. These include severe stomach or abdominal pain, constipation lasting more than three days, difficulty urinating, symptoms of a kidney infection, and mental or mood changes like confusion or hallucinations. Additionally, urgent care is necessary if you experience eye pain, swelling, redness, vision changes, severe allergic reactions such as rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing.

Another serious concern is angioedema, which involves severe swelling of the face, lips, tongue, or throat, and could lead to breathing difficulties. Abnormal heart rhythms, characterized by chest pain, fast or irregular heartbeats, shortness of breath, or feeling faint, also warrant immediate medical intervention. If you notice any effects not mentioned here, consult your healthcare provider.

Solifenacin (Vesicare) can interact with various medications and supplements, so it's essential to inform your doctor and pharmacist about everything you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal products. Some drugs may not be recommended for use with Solifenacin, such as Bepridil, Cisapride, Dronedarone, and certain antifungal medications, like Fluconazole, Itraconazole, and Ketoconazole, because they can alter how Solifenacin is removed from your body, potentially affecting its efficacy. Similarly, using Solifenacin with potassium tablets or capsules is generally not advised.

In some cases, your doctor might prescribe Solifenacin with other medications, but this will often require careful monitoring and possible adjustments in dosage or frequency to ensure safety. These medications include a broad range of drugs like Alfuzosin, Amiodarone, Amitriptyline, Azithromycin, Ciprofloxacin, and many others. Always consult your healthcare provider for guidance tailored to your specific situation.