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Tofacitinib, known by the brand name Xeljanz, is a medication used to treat various inflammatory conditions. It is effective for adults with moderate-to-severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Additionally, it is prescribed for moderate-to-severe polyarticular juvenile idiopathic arthritis in children aged 2 years and older. As a Janus kinase (JAK) inhibitor, tofacitinib works by blocking the JAK protein, which is involved in the body's inflammatory processes. By inhibiting this protein, the drug reduces inflammation, alleviating symptoms such as joint pain, swelling, and tenderness, as well as gastrointestinal symptoms like diarrhea and stomach pain associated with ulcerative colitis. Typically taken orally once or twice a day, tofacitinib is often considered when other treatments have not been effective. However, it is important to be aware of potential side effects, including an increased risk of infections, headaches, and diarrhea, as well as more serious risks like heart problems and blood clots. Always consult healthcare professionals before starting this medication to ensure it is suitable and safe for your condition.