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This medication, which contains estrogen or is used in combination with another hormone like progestin, can potentially lead to serious side effects. It is crucial to discuss the potential risks and benefits of hormone treatment with your healthcare provider. Estrogens should not be utilized for the prevention of heart disease or dementia.

Here are important safety considerations you should be aware of:

• Cancer Risks: Use of estrogen, alone or with progestin, can increase the risk of certain cancers. It can elevate the risk of uterine (endometrial) cancer, especially if used without progestin. Postmenopausal women may also face a higher risk of ovarian cancer, stroke, or dementia. While estrogen alone for up to 7 years does not seem to increase breast cancer risk, combining it with progestin might. Monitor for unusual vaginal bleeding and report it immediately to your doctor.

• Blood Clots and Cardiovascular Risks: Estrogen, alone or with progestin, can heighten the risk of serious blood clots, potentially leading to heart attacks, strokes, or pulmonary embolisms. Risks are higher in individuals with certain conditions, such as tobacco use and a history of blood clots.

• Dementia: Starting estrogen medication at age 65 or older can increase the risk of developing dementia. This medication should not be used as a preventative measure against dementia.

• Gallbladder and Liver Concerns: The medication may cause gallbladder issues, and caution is advised for those with liver problems. If symptoms like jaundice appear, contact your healthcare provider.

• Pancreatitis: Estrogen can increase triglyceride levels, potentially causing pancreatitis. Regular monitoring through blood tests may be recommended by your provider.

• Vaginal Irritation: Some irritation might occur with the use of vaginal insert applicators, particularly if menopause symptoms are severe. Consult your provider if this irritation worsens.

• Eye Problems: Estrogens can cause blood clots in the eyes, leading to serious ocular issues. Report any changes in vision immediately.

In case of an overdose, seek emergency medical assistance promptly.

Contraindications include:

• Undiagnosed abnormal vaginal bleeding.
• History of breast cancer or hormone-dependent cancers.
• Active or historical blood clot issues, arterial thromboembolic disease, or liver damage.
• Pregnancy, specifically with generic estradiol, Vagifem, and Yuvafem.

Always use this medication at the lowest effective dose for the shortest duration necessary and have regular check-ups to reassess the need for continued treatment.

When taking this medication, some patients may experience common side effects such as nausea, vomiting, bloating, diarrhea, breast tenderness, headache, or weight changes. These are generally mild and often resolve on their own. Additionally, some users report vaginal yeast infections, itching in the vaginal area, or back pain. If these symptoms persist or worsen, consult your healthcare provider for advice.

There are also other side effects that have been observed. A small percentage of individuals may experience headaches or diarrhea. Typically, these are not serious but should be discussed with your healthcare provider if they occur.

More severe side effects, although rare, necessitate immediate medical attention. These include persistent nausea and vomiting, significant mental or mood changes like depression or memory loss, breast lumps, and unusual vaginal bleeding or irritation. Signs of liver problems, such as abdominal pain, yellowing of the skin or eyes, and dark urine, should also be promptly addressed.

In very rare cases, this medication can cause potentially fatal blood clots, leading to heart attacks, strokes, or clots in the lungs or legs. Symptoms such as chest pain, sudden headaches, weakness on one side of the body, confusion, or trouble speaking should trigger an urgent medical response. Additionally, allergic reactions, though uncommon, require immediate care, especially if symptoms like rash, swelling, severe dizziness, or breathing difficulties arise. Always consult your healthcare provider if you have concerns or experience any side effects not listed here.