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The information provided below outlines important safety considerations and warnings associated with the use of this medication. It is crucial to review these details and discuss any concerns with your healthcare provider.

• Prolonged Erection (Priapism): Seek immediate medical attention if you experience an erection lasting more than 4 hours after using alprostadil injection, as this can cause permanent damage to the penis. Individuals with a history of conditions such as sickle cell anemia, multiple myeloma, or leukemia should avoid this medication due to increased risk. To reduce the risk, the lowest effective dose will be prescribed, and your healthcare provider will review your dosage every 3 months.

• Penile Scarring: Alprostadil injection may rarely cause scarring, potentially leading to penile curvature. Regular physical examinations will be conducted to monitor for scarring. If detected, discontinuation of the medication may be advised.

• Low Blood Pressure: This medication can lead to low blood pressure, resulting in symptoms like dizziness or fainting. If such symptoms occur, sit down immediately to prevent falls. Taking the lowest possible dose can help mitigate these risks, especially if you are on other blood pressure-lowering medications.

• Bleeding at the Injection Site: Minor bleeding may occur at the injection site. Those on blood thinners or with bleeding disorders are at higher risk. Apply a sterile gauze or alcohol swab for 5 minutes post-injection to reduce bleeding. Discuss with your provider if you are taking blood thinners.

• Heart Problems from Sexual Activity: Sexual activity can strain the heart, particularly in individuals with pre-existing heart problems. If advised against sexual activity due to heart issues, avoid using alprostadil injection. Report any symptoms like chest pain or nausea to your healthcare provider immediately.

• Needle Breakage: The thin needles used for alprostadil injection may break during self-administration, potentially requiring surgical removal. Ensure you understand the proper injection technique and seek guidance if needed.

• Not for Children: Caverject and Caverject Impulse contain benzyl alcohol, which can cause severe side effects in children. Only Prostin VR is used in hospitals for certain newborn conditions. Caverject, Caverject Impulse, and edex are not suitable for children.

• Sexually Transmitted Infections (STIs): Alprostadil injection does not offer protection against STIs, including HIV. To reduce risk, use condoms, get tested regularly, and consider limiting sexual partners. Women of childbearing potential should use effective contraception.

Contraindications: This medication should not be used in individuals with conditions leading to prolonged erections (e.g., sickle cell anemia, leukemia, multiple myeloma), an abnormally shaped penis or Peyronie's disease, or those with penile implants. Consult your healthcare provider if any of these conditions apply to you.

When using this medication, some individuals may experience mild or common side effects. These include mild to moderate pain, irritation, or slight bleeding at the injection site, as well as penile pain, which affects up to 37% of users. Bruising or blood pooling (hematoma) at or near the injection site may also occur. These side effects are generally not serious, but if they persist or worsen, it is advisable to consult a healthcare provider for further guidance.

However, there are more serious side effects that, although rare, require immediate medical attention. These include redness, tenderness, or swelling of the penis, lumps, or unusual curving of the penis, and the development of scar tissue. A prolonged erection lasting four or more hours is particularly concerning and necessitates urgent medical help to prevent permanent complications. Additionally, some users may experience heart-related symptoms such as chest pain, dizziness, or nausea, which also require prompt medical evaluation.

Although a very serious allergic reaction to this medication is uncommon, it is crucial to seek immediate medical assistance if symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing occur. Always consult a healthcare provider if you notice any other side effects not listed here.