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This medication, which contains a combination of estrogen and progestin, is associated with certain risks and precautions. It is crucial to use this treatment under medical supervision and to understand the potential side effects. Below are important safety considerations:

• Serious Health Risks: Estrogen and progestin therapies, including CombiPatch, can increase the risk of blood clots, heart attacks, strokes, and certain cancers such as breast, uterine, and ovarian cancer. They are not recommended for preventing heart disease or dementia. The risk may vary based on personal health history, and these therapies should be used at the lowest effective dose for the shortest duration possible.

• Regular Medical Evaluation: It is advisable to have regular discussions with your doctor, ideally every 3 to 6 months, to determine the continued necessity of this medication. Long-term users should undergo comprehensive physical exams annually, as directed by their healthcare provider.

• Specific Population Considerations:

  • Pregnant Individuals: This medication should not be used during pregnancy.
  • Pre-existing Conditions: Those with a history of blood clots, breast cancer, liver disease, or heart conditions should consult their healthcare provider before use.
  • Age Considerations: Individuals aged 65 and older may face an increased risk of dementia.

• Potential Side Effects:

  • Blood Clots and Cardiovascular Issues: Increased risk for individuals with high blood pressure, diabetes, high cholesterol, and those who use tobacco or are obese.
  • Cancer Risks: History of breast or uterine cancer, previous hormonal therapy, and long-term use may increase cancer risks.
  • Gallbladder and Liver Problems: Watch for symptoms like jaundice, persistent stomach pain, or nausea.
  • Fluid Retention: Can worsen heart failure or kidney damage.
  • High Triglycerides: May lead to pancreatitis; monitor for symptoms like stomach pain or fever.
  • Thyroid and Calcium Levels: Can affect those with low thyroid hormone levels or certain cancers.

• Contraindications: Do not use if you have unexplained vaginal bleeding, current or past breast cancer, estrogen-dependent tumors, recent blood clots, history of heart attack or stroke, or known liver damage.

In case of an overdose or severe side effects, seek emergency medical attention immediately. Always discuss any concerns or symptoms with your healthcare provider to ensure safe and effective use of this medication.

When using this medication, some individuals may experience common side effects that are generally mild and should not cause alarm. These include breast pain, menstrual cramps, headaches, vaginitis (which may present as vaginal pain, itching, burning, or discharge), weakness, breathing problems, irregular vaginal bleeding, back pain, nausea, and sore throat. Application site reactions such as irritation, itchiness, redness, or swelling, as well as general pain, stomach pain, diarrhea, indigestion, passing gas, flu-like symptoms, runny nose, sinus infection, depression, trouble sleeping, and nervousness can also occur. While these side effects are usually not serious, it's important to consult a healthcare provider if they persist or worsen.

However, there are rare but serious side effects that necessitate immediate medical attention. These include the formation of blood clots in the arms or legs, characterized by swelling, pain, or tenderness, and warm skin. Blood clots in the lungs can manifest as chest pain and difficulty breathing. Symptoms of a heart attack, such as chest or arm pain, shortness of breath, cold sweat, and lightheadedness, and indications of a stroke, including sudden weakness on one side of the body, facial drooping, speech or vision changes, confusion, and a severe headache, require urgent care. Additionally, a severe allergic reaction may present with hives, itchiness, stomach pain, vomiting, breathing difficulties, and swelling of the face, lips, or tongue, and should be addressed immediately.

Always be vigilant about the side effects you experience, and reach out to a healthcare professional for advice or assistance if you notice any concerning symptoms.

When using CombiPatch (estradiol/norethindrone), it is important to be aware of potential drug interactions. This medication should not be taken with Tranexamic Acid. In cases where CombiPatch must be combined with certain other medications, such as aromatase inhibitors (like Anastrozole, Exemestane, Letrozole), fezolinetant, Fulvestrant, ospemifene, Raloxifene, Tamoxifen, and Toremifene, your doctor might need to adjust the dosage or frequency of either medication to manage the interaction effectively.

Additionally, CombiPatch may interact with a wide range of other medications, including antibiotics like Amoxicillin and Ampicillin, anticonvulsants like Carbamazepine and Phenytoin, as well as herbal supplements such as St. John's Wort. These interactions could decrease the effectiveness of CombiPatch or increase the risk of side effects. Your healthcare provider will determine the best course of action if you need to take CombiPatch alongside these medications.

Moreover, this medication can interfere with certain laboratory tests, such as the metyrapone test, potentially leading to false results. It is crucial to inform all medical personnel and your doctors that you are using CombiPatch to ensure accurate test outcomes and appropriate medical care. Always discuss all medications and supplements you are taking with your healthcare provider to avoid potential interactions.