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The following safety information outlines crucial warnings and precautions associated with the use of ertapenem (Invanz). Please read them carefully and consult with your healthcare provider if you have any questions or concerns.

• Allergic Reactions: There is a potential for serious allergic reactions to ertapenem. These reactions may include symptoms such as hives, facial swelling, and, in severe cases, anaphylaxis, which can result in shock or throat closure. If you have known allergies to antibiotics, particularly penicillin or cephalosporin, inform your healthcare provider to ensure ertapenem is appropriate for you. Seek immediate medical attention if you experience symptoms like a rash, red skin, swelling of the lips or tongue, or difficulty breathing during treatment.

• Nervous System Side Effects: Although uncommon, ertapenem may cause serious nervous system side effects such as seizures, delirium, or hallucinations. These are more likely if you have a history of seizures, brain issues, kidney problems, or are taking medications like valproic acid or divalproex sodium. If you or those around you notice these symptoms, call emergency services immediately. These effects typically resolve after discontinuing the medication.

• Clostridioides difficile Infection Risk: Use of ertapenem can increase the risk of a Clostridioides difficile infection, leading to potentially life-threatening diarrhea. This occurs because antibiotics can disrupt the balance of normal bacteria in your gut, allowing C. diff to proliferate. Monitor for severe diarrhea and consult your healthcare provider if symptoms arise.

• Development of Drug-Resistant Bacteria: It is important to use ertapenem strictly as prescribed to avoid the development of drug-resistant bacteria. Deviating from the prescribed duration or using the antibiotic for non-intended illnesses increases the risk of difficult-to-treat infections.

Contraindications indicate specific conditions where the use of ertapenem is not advised due to serious health risks:

• Known allergy to penicillins, cephalosporins, or other beta-lactam antibiotics.
• Allergy to local anesthetics like lidocaine when administered intramuscularly.

Ensure you discuss any of these conditions with your healthcare provider before starting treatment with ertapenem.

When taking this medication, some people may experience mild side effects such as swelling, redness, pain, or soreness at the injection site. Upset stomach, headache, nausea, vomiting, and diarrhea are also common but typically not severe. For women, vaginal irritation may occur. If these symptoms persist or worsen, consult a healthcare provider for guidance.

In some cases, more noticeable side effects like stomach pain, dizziness, shortness of breath, itching, and rash can be observed. While these are less common, it is important to monitor them and seek medical advice if they become bothersome or severe.

There are also rare but serious side effects that require immediate medical attention. These include seizures, unusual weakness, and symptoms of a serious allergic reaction such as rash, severe dizziness, trouble breathing, and swelling of the face, tongue, or throat. The medication might also rarely cause a severe intestinal condition linked to C. difficile bacteria. Symptoms include persistent diarrhea, abdominal pain, cramps, and blood or mucus in the stool. Immediate medical care is necessary if these occur and it's crucial not to use anti-diarrhea or opioid products, as they can worsen the condition.

Prolonged use of this medication may lead to oral thrush or a new yeast infection. Look for white patches in the mouth or changes in vaginal discharge, and contact your doctor if these symptoms appear. Always remain vigilant for any other unexpected effects and report them to a healthcare professional.

Ertapenem (Invanz) can interact with certain medications, so it's crucial to inform your healthcare provider about all the drugs and supplements you are currently using, whether they are prescription, over-the-counter, vitamins, or herbal products.

Valproic acid and similar medications, such as divalproex sodium and sodium valproate, may interact with Ertapenem. This combination is generally not recommended, but if necessary, your doctor might adjust the dosage or frequency of one or both medications.

Additionally, interactions with the Cholera Vaccine, Live are usually discouraged, but if both are needed, your healthcare provider will closely monitor and adjust the treatment plan accordingly.

There can also be an increased risk of side effects when Ertapenem is used with Probenecid or Tacrolimus. Nevertheless, in some cases, using these medications together might be the most effective treatment option. Your doctor will manage the dosing schedule and monitor any potential side effects to ensure safe use.