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This safety information outlines important warnings and contraindications associated with the use of methylergonovine (Methergine). It is crucial to be fully informed of these risks and precautions. If you have any questions or concerns, please speak with your healthcare provider.

• Breastfeeding Warning: Avoid breastfeeding while taking methylergonovine (Methergine) and for at least 12 hours after the last dose. This medication can transfer into breast milk and may harm your infant. Additionally, methylergonovine may reduce milk production, so a decrease in milk supply is expected during treatment.

• Heart Attack Risk: Methylergonovine may cause blood vessels to constrict, reducing blood flow to the heart, which can result in heart damage or a heart attack. This risk is higher for individuals with existing heart artery issues or those at elevated risk for heart problems, such as smokers, or those with obesity, diabetes, or high cholesterol. It is essential to disclose all medical conditions to your healthcare provider. Seek immediate medical attention if you experience symptoms such as chest pain, tightness, pain spreading to the left arm or neck, or difficulty breathing, as these may indicate a heart attack.

• Contraindications: The use of methylergonovine is not recommended for individuals with the following conditions, as it may lead to severe health complications:

  • High blood pressure
  • Preeclampsia (high blood pressure during pregnancy)
  • Current pregnancy

Consult your healthcare provider if any of the above conditions apply to you before using this medication.

When taking this medication, you might experience some mild side effects, such as headache, nausea, vomiting, or dizziness. These are generally not serious but should be reported to a healthcare provider if they persist or worsen. Some individuals may also encounter high blood pressure, which can lead to headaches, or low blood pressure. Stomach pain related to uterine contractions can also occur. While these side effects are common, they typically do not require serious intervention unless they become severe.

However, there are some serious side effects associated with this medication that require immediate medical attention. These include fast or slow heartbeat, shortness of breath, cold hands or feet, and pain or redness in the arms or legs. Rare but very serious reactions include chest pain, vision changes, confusion, and seizures, which could indicate a heart attack or extremely high blood pressure. Additionally, while a severe allergic reaction is rare, symptoms such as rash, swelling, severe dizziness, or trouble breathing necessitate urgent medical help.

It is important to monitor your symptoms and consult with a healthcare provider if you notice any other effects not listed here. Your wellbeing is paramount, and prompt attention to unusual symptoms can prevent complications.

Methylergonovine (Methergine) can interact with a variety of medications, impacting its effectiveness and safety. It is important to inform your healthcare provider about all medications and supplements you are currently taking, including prescription, over-the-counter, vitamins, and herbal products.

Interactions can occur with specific drugs, notably other ergot alkaloids like ergotamine and dihydroergotamine, as well as triptan medications used for migraines, such as eletriptan, rizatriptan, and sumatriptan. These combinations are generally not recommended due to potential adverse effects.

Certain medications can influence how methylergonovine is metabolized in the body. These include drugs like adagrasib, cobicistat, mifepristone, nefazodone, and various azole antifungals (itraconazole, ketoconazole), macrolide antibiotics (erythromycin, clarithromycin), and HIV protease inhibitors (such as lopinavir and ritonavir). These interactions may require adjustments in dosage or the frequency of administration.

Additionally, the use of methylergonovine with medications like dobutamine, dopamine, ephedrine, epinephrine, fluconazole, fluvoxamine, norepinephrine, phenylephrine, propatyl nitrate, and vasopressin is generally not recommended unless necessary. In such cases, your doctor may need to adjust how you use one or both medications to mitigate potential risks. Always consult with your healthcare provider for guidance tailored to your specific situation.