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This medication is designed to treat or prevent specific types of headaches, such as migraines and cluster headaches, which are caused by widened blood vessels. The combination of ergotamine and caffeine works by constricting these blood vessels, thereby alleviating the headache pain. Ergotamine, part of the ergot derivative class, and caffeine, a nonselective PDE inhibitor, work together to not only tighten blood vessels but also soothe certain brain areas to relieve headache symptoms. This drug comes in two forms: an oral tablet and a rectal suppository. The suppository form is particularly useful if oral administration is not possible due to nausea or vomiting. It is important to use this medication at the onset of headache symptoms but adhere to dosage limits to avoid potential serious side effects such as vomiting and numbness. Always consult with a healthcare professional before starting any new medication.