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The following information outlines critical safety warnings and precautions regarding the use of PEG 3350/electrolytes bowel preparation. Please read carefully and discuss any concerns with your healthcare provider.

• Fluid and Electrolyte Imbalance: This medication may lead to dehydration and imbalances in electrolyte levels, potentially causing serious health issues such as heart rhythm disturbances, seizures, and kidney problems. Ensure proper hydration before, during, and after using this medication. Contact your healthcare provider immediately if you experience excessive vomiting, dizziness, headaches, or dark urine, as these may indicate dehydration.

• Heart Rhythm Concerns: Though rare, this medication can cause significant changes in heart rhythm, including arrhythmias. Monitor for symptoms such as chest fluttering, difficulty breathing, or chest pain. Patients with a history of heart conditions should inform their healthcare provider, who may perform heart checks before and after the use of this medication.

• Seizure Risk: The medication can induce seizures due to electrolyte imbalance, even in those without a history of seizures. Stay adequately hydrated and seek medical attention if you feel faint or confused, as these may be early signs of a seizure.

• Kidney Health: Different brands of bowel preparation have varying electrolyte contents. Consult with your healthcare provider to select the appropriate brand, especially if you have pre-existing kidney issues. The risk of kidney damage increases if you are taking other kidney-affecting medications. Maintain adequate hydration to minimize this risk.

• Colon Damage: PEG 3350/electrolytes may cause colon damage, including ulcers. Do not use stimulant laxatives concurrently. Alert your healthcare provider if you have a history of stomach ulcers, blockages, or inflammation, as an alternative medication may be necessary.

• Swallowing Difficulties: Large quantities of liquid are required with this medication. If you have swallowing or gag reflex issues, proceed with caution to avoid aspiration. Do not mix this medication with liquids thickened with starch-based thickeners, as PEG can thin them, increasing the risk of choking. Consult your provider if you encounter difficulties.

• Use Caution with Specific Conditions: Individuals with low glucose-6-phosphate dehydrogenase (G6PD) levels or phenylketonuria (PKU), particularly those using Moviprep and Plenvu, should exercise caution, as these formulations contain ingredients that may harm red blood cells.

Contraindications: This medication should not be used if you have any of the following conditions, as it may lead to severe health risks:

• Gastrointestinal obstruction (stomach blockage)
• Bowel perforation (tear in the intestine wall)
• Toxic colitis (severe colon inflammation)
• Toxic megacolon (extreme swelling of the intestine)
• Gastric retention (delayed stomach emptying)
• Ileus (inability of the bowel to move waste)

Consult your healthcare provider if you have any of these contraindications before using PEG 3350/electrolytes bowel preparation.

When taking this medication, you might experience common side effects such as watery bowel movements, nausea, bloating, a feeling of fullness in the stomach, stomach cramps, and vomiting. These are usually mild but if they persist or worsen, it's advisable to consult your healthcare provider. Some individuals may also experience anal irritation, shivering, trouble sleeping, increased hunger and thirst, and tiredness, especially with certain formulations like Moviprep.

In addition to these, some users have reported other side effects such as headaches, changes in electrolyte levels, and upper stomach bleeding. These effects are generally less common, but attention should be paid to them if they occur.

Serious side effects, although rare, require immediate medical attention. These include symptoms related to kidney problems such as weakness, drowsiness, and reduced urination, as well as signs of electrolyte imbalance which can manifest as vomiting, stomach cramps, dizziness, and a fast heart rate. Other severe reactions include colon ulcers, characterized by severe stomach pain and rectal bleeding, heartbeat irregularities, seizures, and choking. A very serious allergic reaction, although rare, could occur, presenting with symptoms like rash, itching, swelling, severe dizziness, and trouble breathing. If you experience any of these severe symptoms, seek urgent medical care.

When using PEG 3350/electrolytes bowel prep, it's important to be aware of potential interactions with other medications or supplements you might be taking. This includes both prescription and over-the-counter medications, as well as vitamins, dietary, and herbal supplements. Before starting this medication, inform your doctor and pharmacist about all the substances you are currently taking.

Certain medications should not be combined with PEG 3350/electrolytes, as these combinations may not be recommended. Your doctor might choose to discontinue one of the medications or adjust the dosage of your current treatments. Such medications include: Amantadine, Atropine, Belladonna and its derivatives, Benztropine, Biperiden, Clidinium, Darifenacin, Dicyclomine, Eplerenone, Fesoterodine, Glycopyrrolate, Hyoscyamine, Methscopolamine, Oxybutynin, Procyclidine, Scopolamine, Solifenacin, Tolterodine, Trihexyphenidyl, and Trospium.

In some cases, it might be necessary to use PEG 3350/electrolytes with other medications that are usually not recommended to be combined with it. If prescribed together, your doctor may adjust how often you use one or both medications. These medications include: Acalabrutinib, Alacepril, Amiloride, Amphetamine, Benazepril, Benzphetamine, Bisacodyl, Cabotegravir, Canrenoate, Captopril, Cilazapril, Delapril, Dextroamphetamine, Digoxin, Erdafitinib, Fosinopril, Gefitinib, Imidapril, Indomethacin, Ketoconazole, Ledipasvir, Licorice, Lisdexamfetamine, Lisinopril, Mefenamic Acid, Memantine, Methamphetamine, Moexipril, Neratinib, Octreotide, Pazopanib, Pentopril, Perindopril, Quinapril, Ramipril, Rilpivirine, Selpercatinib, Senna, Sodium Picosulfate, Spirapril, Spironolactone, Temocapril, Trandolapril, Triamterene, and Zofenopril.

Finally, using PEG 3350/electrolytes with medications such as Chloroquine and Licorice may increase the risk of certain side effects. Nonetheless, using both together might be the best treatment option for you. Your doctor may adjust the dosage or frequency of these medications to manage side effects effectively. Always follow your healthcare provider's instructions and report any unusual symptoms promptly.