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The information below outlines essential safety warnings and precautions associated with the use of this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Dehydration and Electrolyte Imbalance: To prevent severe dehydration and electrolyte disturbances, it is crucial to consume plenty of fluids before, during, and after using Suprep. Should you experience severe vomiting or symptoms of dehydration, your healthcare provider may conduct lab tests to monitor your electrolytes, kidney function, and hydration status. Imbalances can lead to serious issues such as irregular heartbeats, seizures, or kidney complications.

  • Risks Include: Severe vomiting, concomitant medications causing dehydration or imbalances, and gout.

• Heart Rhythm Concerns: Rare instances of serious heart rhythm disruptions, including arrhythmias, have been reported with osmotic laxatives like Suprep used for bowel preparation. If you have an increased risk of heart problems, your healthcare provider may perform an electrocardiogram (ECG) before and after your procedure.

  • Risks Include: Previous heart rhythm issues, recent heart attack, unstable chest pain, congestive heart failure, and cardiomyopathy.

• Seizure Risk: There have been reports of seizures or fainting following the use of Suprep, even in individuals without a prior history of seizures. These incidents are often linked to imbalances in electrolytes such as sodium, potassium, calcium, or magnesium.

  • Risks Include: History of seizures, benzodiazepine or alcohol withdrawal, low sodium levels, and concurrent medications that increase seizure risk.

• Kidney Health: If you have existing kidney issues or are taking medications that may affect kidney function—such as diuretics, ACE inhibitors, angiotensin receptor blockers, or NSAIDs—it is important to discuss this with your healthcare provider before using Suprep. Staying hydrated is essential, and kidney function may be evaluated with lab tests before and after your procedure.

  • Risks Include: Pre-existing kidney problems and concurrent use of kidney-affecting medications.

• Colon Issues: Suprep and similar osmotic laxatives may cause small ulcers in the colon, and in rare cases, lead to ischemic colitis, a condition that reduces blood flow to the colon and may require hospitalization. Combining Suprep with stimulant laxatives can increase these risks, so consult your healthcare provider before using additional laxatives.

  • Risks Include: Inflammatory bowel disease (IBD), use of stimulant laxatives, severe ulcerative colitis.

• Choking Hazard: Individuals with difficulty swallowing or a compromised gag reflex may be at risk of choking or aspirating Suprep. Inform your healthcare provider if you have these issues prior to starting the medication.

  • Risks Include: Trouble swallowing and poor gag reflex.

Contraindications: Suprep should not be used if you have any of the following conditions, as it may pose serious health risks:

• Intestinal obstruction (blockage in the gut)
• Bowel perforation (hole in the bowel)
• Toxic megacolon (severe colon swelling)
• Gastric retention (improper stomach emptying)

Always consult your healthcare provider if any of these contraindications apply to you or if you have concerns about using Suprep.

When taking this medication, some individuals may experience common side effects such as very watery bowel movements, nausea, bloating, vomiting, and abdominal cramping. These effects are generally mild and tend to improve over time. However, if they persist or worsen, it is advisable to consult a healthcare professional for guidance.

In some cases, this medication can lead to more significant issues like dehydration or electrolyte imbalances. Symptoms to watch for include severe dizziness, fainting, fast or irregular heartbeat, headaches, and difficulty retaining fluids. Prolonged vomiting or any signs of kidney problems, such as changes in urine output, should not be ignored and require prompt medical attention.

Additionally, be vigilant for serious side effects, such as persistent or severe stomach pain, bloody stools, or rectal bleeding. These symptoms may indicate a more serious condition and warrant immediate medical evaluation. Although rare, allergic reactions can occur. Look out for signs such as rash, itching, swelling, particularly of the face, tongue, or throat, severe dizziness, and trouble breathing. Seek emergency help if these symptoms appear.

Remember, while many people taking this medication do not encounter severe side effects, it is crucial to be aware of them and act promptly should they arise. Always discuss any new or unexpected symptoms with your healthcare provider to ensure your safety and well-being while on this medication.