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The following information outlines important safety warnings and precautions for the use of rosuvastatin (Crestor). It is crucial to understand these risks and consult with your healthcare provider if you have any questions or concerns.

• Severe Muscle Pain and Damage: Rosuvastatin may lead to a rare but serious condition known as rhabdomyolysis, which can result in kidney injury. This risk is heightened if you are taking other medications that increase rosuvastatin levels or cause muscle damage. Discontinue use immediately and seek medical attention if you experience symptoms such as severe muscle pain, tenderness, weakness, dark urine, or fatigue. Increased risk factors include being over 65, of Asian descent, having uncontrolled hypothyroidism, taking high doses of rosuvastatin, having kidney issues, or using other interacting medications.

• Liver Problems: Some users of rosuvastatin have experienced changes in liver enzyme levels, indicating potential liver issues. While these changes are often temporary and symptomless, serious liver problems, including liver failure, have been reported in rare instances. Those with a history of liver issues or who consume large amounts of alcohol are at greater risk.

• Elevated Blood Sugar Levels: There is evidence that rosuvastatin may increase blood sugar, affecting hemoglobin A1C levels. Despite this, the benefits of rosuvastatin are generally considered to outweigh this risk. Inform your healthcare provider if you have diabetes or elevated blood sugar before starting rosuvastatin, as you may need to monitor your blood sugar more frequently. Maintaining a balanced diet and regular exercise is recommended while on this medication.

• Potential Harm During Pregnancy or Breastfeeding: Rosuvastatin is generally not recommended during pregnancy or breastfeeding, as it may harm the fetus or nursing infant. Discuss alternative treatments with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Contraindications: Do not use rosuvastatin if you have severe liver issues, such as liver failure or cirrhosis, or if you are currently pregnant or breastfeeding, as these conditions can pose significant health risks. Always consult your healthcare provider if you have concerns regarding these contraindications.

When taking rosuvastatin, it's important to be aware of both common and rare side effects. Common side effects include muscle pain, joint pain, headache, nausea, and constipation. These are usually mild but if they persist or worsen, consulting with a healthcare provider is advisable.

Other side effects that some individuals may experience include stomach pain, dizziness, rash, itchy skin, hives, and increased blood sugar levels. While these are not as common, monitoring your health for these symptoms is wise, and reaching out to your healthcare provider if they occur is recommended.

Rare but serious side effects require immediate medical attention. This includes severe muscle damage, known as rhabdomyolysis, which can present as dark brown urine, severe muscle weakness or pain, fever, and tiredness. Liver issues are also critical; symptoms like yellowing of the skin or eyes, persistent nausea or vomiting, dark urine, and abdominal pain are indicators of potential liver problems. Additionally, a serious allergic reaction, while rare, demands urgent medical help if symptoms such as rash, itching or swelling, dizziness, or trouble breathing arise.

Remember, this is not an exhaustive list of side effects. If you notice any other unusual symptoms, contacting a healthcare provider is essential for guidance and care.

Rosuvastatin, commonly known as Crestor, can interact with various medications and supplements. It is important to inform your doctor and pharmacist about all the medications and supplements you are currently taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products.

Certain medications, such as amprenavir, Atazanavir, bezafibrate, and Cyclosporine, among others, may not be recommended for use with rosuvastatin, but if necessary, your doctor might adjust the dosage or frequency. The interaction with these medicines can alter rosuvastatin's effectiveness or increase the risk of side effects.

Additionally, using rosuvastatin with medications like acenocoumarol, Amiodarone, and Fluconazole may heighten the risk of side effects, yet in some cases, the combined use might be beneficial. Your healthcare provider may need to modify the dosages accordingly.

It's crucial to avoid Red Yeast Rice products while on rosuvastatin. These products may contain Lovastatin, another statin, and using them together can significantly increase the risk of severe muscle and liver complications.