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Here is an important summary of safety precautions and warnings for simvastatin (Zocor). Please review these carefully and discuss any concerns with your healthcare provider.

• Severe Muscle Pain and Damage: Simvastatin (Zocor) may rarely cause a serious muscle condition known as rhabdomyolysis, which can be life-threatening. The risk increases if you are taking medications that elevate simvastatin levels in your body. Consult your healthcare provider or pharmacist before starting any new medications. Discontinue simvastatin (Zocor) immediately and seek medical attention if you experience severe muscle pain, dark urine, weakness, or fatigue. Higher risk factors include being over 65 years of age, higher doses of simvastatin, kidney issues, use of other medications that may cause muscle issues, or unmanaged hypothyroidism.

• Liver Problems and Liver Failure: Simvastatin (Zocor) can cause severe liver issues, potentially leading to liver failure, though this is rare. Liver function tests may be required before and during treatment. Promptly seek medical help if you notice abdominal swelling, stomach pain, jaundice, changes in stool color, nausea, vomiting, confusion, or dark urine. You may need to discontinue the medication to prevent further liver damage. Risk factors include a history of liver problems and excessive alcohol consumption.

• Increased Blood Sugar Levels: Simvastatin (Zocor) may elevate blood sugar levels, potentially affecting hemoglobin A1C levels. Despite this risk, healthcare providers generally consider the benefits of statins to outweigh the risks. Inform your healthcare provider if you have high blood sugar before starting treatment, as you may need more frequent monitoring. Maintain a balanced diet and regular exercise while on this medication.

• Risks During Pregnancy and Breastfeeding: Simvastatin (Zocor) is generally not recommended during pregnancy or breastfeeding due to potential harm to the unborn or nursing baby. Discuss safe alternatives with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Contraindications: Do not use simvastatin (Zocor) if you are taking certain medications, such as azole antifungals, macrolide antibiotics, specific antiviral drugs, nefazodone, cyclosporine, or gemfibrozil, as these combinations can be hazardous. This medication is also contraindicated for individuals with liver problems and should not be used during pregnancy and breastfeeding (specifically for Flolipid). Always consult your healthcare provider for personalized advice.

Common side effects:

• Cough
• Runny nose
• Stomach pain
• Irregular heartbeat
• Nausea
• Eczema
• Dizziness

Less common but important to monitor:

• Difficulty sleeping
• Muscle pain
• Urinary tract infections
• Swelling in hands, legs, or feet
• Headaches
• Sinus infections
• Constipation

Serious side effects:

• Rhabdomyolysis
• Autoimmune myopathy
• Severe muscle weakness or pain
• Dark brown urine
• Fever
• Unusual tiredness
• Diabetes exacerbation
• Liver problems
• Yellowing of the skin or eyes
• Dark urine
• Abdominal pain
• Serious allergic reactions (rash, severe dizziness, swelling, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Amprenavir
• Atazanavir
• Boceprevir
• Clarithromycin
• Cobicistat
• Cyclosporine
• Danazol
• Darunavir
• Erythromycin
• Fosamprenavir
• Gemfibrozil
• Idelalisib
• Indinavir
• Itraconazole
• Ketoconazole
• Letermovir
• Lopinavir
• Mibefradil
• Mifepristone
• Nefazodone
• Nelfinavir
• Paritaprevir
• Posaconazole
• Ritonavir
• Saquinavir
• Telaprevir
• Telithromycin
• Tipranavir
• Voriconazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acenocoumarol
• Amiodarone
• Amlodipine
• Azithromycin
• Bempedoic Acid
• Bezafibrate
• Carbamazepine
• Ceritinib
• Ciprofibrate
• Ciprofloxacin
• Clofibrate
• Colchicine
• Conivaptan
• Dabigatran Etexilate
• Dalfopristin
• Daptomycin
• Darolutamide
• Delavirdine
• Diltiazem
• Dronedarone
• Duvelisib
• Eltrombopag
• Enasidenib
• Eslicarbazepine Acetate
• Fenofibrate
• Fenofibric Acid
• Fluconazole
• Fosnetupitant
• Fusidic Acid
• Glecaprevir
• Ivosidenib
• Larotrectinib
• Lefamulin
• Leflunomide
• Levamlodipine
• Lomitapide
• Lorlatinib
• Lumacaftor
• Netupitant
• Niacin
• Pazopanib
• Pibrentasvir
• Quinupristin
• Ranolazine
• Risperidone
• Simeprevir
• Tadalafil
• Teriflunomide
• Verapamil
• Warfarin

Interactions with low risk that usually do not require a change in therapy:

• Albiglutide
• Alitretinoin
• Bosentan
• Cilostazol
• Clopidogrel
• Digoxin
• Efavirenz
• Fosphenytoin
• Fostemsavir
• Interferon Beta
• Levothyroxine
• Oat Bran
• Oxcarbazepine
• Pectin
• Phenytoin
• Rifampin
• St John's Wort
• Ticagrelor