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Rilpivirine, marketed under the name Edurant, is an antiretroviral medication used to manage HIV-1 infection. It is typically prescribed to individuals aged 2 and older, who weigh at least 30 pounds, and have not previously received HIV treatment. The medication is taken orally once a day in combination with other HIV medications. It works by inhibiting the reverse transcriptase enzyme, which the virus needs to replicate. This action helps reduce the viral load in the body, allowing the immune system to function more effectively and lowering the risk of HIV-related complications such as infections and cancer. Edurant is also used short-term in individuals aged 12 and older, weighing at least 77 pounds, who are transitioning to Cabenuva (a combination of cabotegravir and rilpivirine) or may miss a dose of it. While Rilpivirine is not a cure for HIV, consistently taking it as prescribed, along with using barrier methods during sexual activities, helps prevent the spread of the virus. Common side effects include depression, headache, and trouble sleeping. It's essential to consult with healthcare professionals such as doctors, nurses, or pharmacists for personalized advice and to ensure the safe and effective use of this medication.