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Efavirenz, also known as Sustiva, is a medication used in combination with other antiretroviral drugs to manage HIV infections in individuals aged three months and older. It is classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI) and works by blocking an enzyme called reverse transcriptase. This action prevents HIV from replicating and spreading, thereby reducing the amount of the virus in the body. Consequently, this helps strengthen the immune system and lowers the risk of developing complications such as infections and cancer, ultimately enhancing quality of life. Efavirenz is available in oral tablets and capsules. For those who have difficulty swallowing, the capsules can be opened and mixed with liquid. While it is not a cure for HIV, continuing treatment as prescribed is crucial for effectiveness. It is also important to use barrier methods like condoms during sexual activity and avoid sharing personal items that may come into contact with blood or body fluids to reduce the risk of transmitting the virus to others. Common side effects of Efavirenz include rash, diarrhea, and nausea. It is available as both a brand-name and generic medication. Always consult your healthcare provider for personalized medical advice and follow their instructions closely.