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Etravirine, also known by its brand name Intelence, is a medication used in combination with other antiretroviral drugs to manage HIV infections. This medication is primarily prescribed for individuals aged 2 years and older who have developed resistance to other HIV treatments. Etravirine works by inhibiting the action of reverse transcriptase, an enzyme that HIV uses to replicate within the body. By blocking this enzyme, etravirine helps reduce the amount of HIV, allowing the immune system to function more effectively and decreasing the risk of complications such as infections and cancer. While etravirine is not a cure for HIV, its use can significantly improve the quality of life for those living with the virus. It is important to continue taking all HIV medications as directed by a healthcare provider and to use effective barrier methods, like condoms or dental dams, during sexual activity to minimize the risk of transmission. Etravirine is available in tablet form and can be taken whole or dissolved in liquid for those who have difficulty swallowing. Some potential side effects include changes in cholesterol levels and skin rashes. Always consult your healthcare provider for personalized advice and guidance on the use of etravirine or any other medications.